thymidylate synthase

Raltitrexed is an anti-tumor drug for advanced colorectal cancer. Raltitrexed is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Product Name: Raltitrexed CAS No.: 112887-68-0 Assay: 99%

5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid is used as intermediate of Raltitrexed. Product Name: 5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid CAS No.: 131052-68-1 Assay: 98% End Use: Raltitrexed Molecular Formula: C11H15NO4S Molecular Weight: 257.3 Shelf Life: 2 Years Package: 25kg/drum

6-Bromomethyl-3,4-dihydro-2-methyl-quinazolin-4-one is an intermediate of Raltitrexed. Product Name: 6-Bromomethyl-3,4-dihydro-2-methyl-quinazolin-4-one CAS No.: 112888-43-4 Assay: 98% End Use: Raltitrexed Molecular Formula: C10H9BrN2O Molecular Weight: 253.1 Shelf Life: 2 Years Package: 25kg/drum

5-Nitrothiophene-2-carboxylicacid is an intermediate of Raltitrexed Product Name: 5-Nitrothiophene-2-carboxylicacid CAS No.: 6317-37-9 Assay: 98% End Use: Raltitrexed Molecular Formula: C5H3NO4S Molecular Weight: 173.15 Shelf Life: 2 Years Package: 25kg/drum

Pralatrexate, an injectable DHFR inhibitor, was launched for the treatment of patients with relapsed or refractory PTCL. The inhibition of the folate enzymes DHFR and thymidylate synthase is a well-validated method of cancer treatment. Product Name: Pralatrexate CAS No.: 52853-40-4 Assay: 989% Specification: CP, EP, In-house, as required Molecular Formula: C23H23N7O5 Molecular Weight: 477.47 Shelf Life: 2 Years Package: 25kg/drum